InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mypn

Summary

InnateDB Protein

IDBP-158972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mypn

Protein Name

myopalladin

Synonyms

1110056A04Rik; 9830112J03; AI853556; mKIAA4170;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093240

InnateDB Gene

IDBG-158970 (Mypn)

Protein Structure

UniProt Annotation

Function

Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere. Note=Bound to sarcomere both at the Z-line periphery and in the central I-band region.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0017124	SH3 domain binding
GO:0051371	muscle alpha-actinin binding

Biological Process

GO:0045214

sarcomere organization

Cellular Component

GO:0005634	nucleus
GO:0015630	microtubule cytoskeleton
GO:0030018	Z disc
GO:0031674	I band

Protein Structure and Domains

PDB ID

MGI:1916052

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5DTJ9