Homo sapiens Protein: RTN4RL1
Summary
InnateDB Protein IDBP-15908.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN4RL1
Protein Name reticulon 4 receptor-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330631
InnateDB Gene IDBG-15906 (RTN4RL1)
Protein Structure
UniProt Annotation
Function May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. {ECO:0000303PubMed:14664809}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12694398}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:12694398}. Note=Localized to the surface of neurons, including axons.
Disease Associations
Tissue Specificity Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. {ECO:0000269PubMed:12694398, ECO:0000269PubMed:14664809}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0031103 axon regeneration
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UN2
PhosphoSite PhosphoSite-Q86UN2
TrEMBL
UniProt Splice Variant
Entrez Gene 146760
UniGene Hs.22917
RefSeq NP_848663
HUGO HGNC:21329
OMIM 610461
CCDS CCDS45569
HPRD 11523
IMGT
EMBL AF532859 AL834409 AY250219 BC128608 BK001305 CH471108
GenPept AAI28609 AAP21836 AAP82836 CAD39071 DAA01388 EAW90570