Version 5.4
Mus musculus Protein: Crabp2
Summary
InnateDB Protein IDBP-159185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crabp2
Protein Name cellular retinoic acid binding protein II
Synonyms AI893628; Crabp-2; CrabpII;
Species Mus musculus
Ensembl Protein ENSMUSP00000005019
InnateDB Gene IDBG-159183 (Crabp2)
Protein Structure
UniProt Annotation
Function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. {ECO:0000269PubMed:10490651}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10490651}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000269PubMed:10490651}. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Disease Associations
Tissue Specificity Embryo and skin of adult mouse.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005215 transporter activity
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0002138 retinoic acid biosynthetic process
GO:0006810 transport
GO:0035115 embryonic forelimb morphogenesis
GO:0042573 retinoic acid metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:88491
InterPro IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR011038 Calycin-like
PFAM PF00061
PF08212
PRINTS PR00178
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22935
PhosphoSite PhosphoSite-P22935
TrEMBL
UniProt Splice Variant
Entrez Gene 12904
UniGene Mm.4757
RefSeq NP_031785
MGI ID
MGI Symbol Crabp2
OMIM
CCDS CCDS17460
HPRD
IMGT
EMBL BC018397 M35523 M87538 M87539
GenPept AAA37452 AAA37454 AAH18397

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca