InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nes

Summary

InnateDB Protein

IDBP-159222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nes

Protein Name

nestin

Synonyms

AA166324; C78523; ESTM46;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088493

InnateDB Gene

IDBG-159220 (Nes)

Protein Structure

UniProt Annotation

Function

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. {ECO:0000250, ECO:0000269PubMed:20963821}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0019215	intermediate filament binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007399	nervous system development
GO:0007420	brain development
GO:0030844	positive regulation of intermediate filament depolymerization
GO:0031076	embryonic camera-type eye development
GO:0032091	negative regulation of protein binding
GO:0043086	negative regulation of catalytic activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0048858	cell projection morphogenesis
GO:0072089	stem cell proliferation
GO:2000179	positive regulation of neural precursor cell proliferation