InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esrrb

Summary

InnateDB Protein

IDBP-159270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esrrb

Protein Name

estrogen related receptor, beta

Synonyms

Err2; Errb; Estrrb; Nr3b2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021680

InnateDB Gene

IDBG-159268 (Esrrb)

Protein Structure

UniProt Annotation

Function

Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	96 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001831	trophectodermal cellular morphogenesis
GO:0001834	trophectodermal cell proliferation
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0019827	stem cell maintenance
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1346832

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt