Mus musculus Protein: Mpdz | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-159282.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mpdz | ||||||||||||||||||||||
Protein Name | multiple PDZ domain protein | ||||||||||||||||||||||
Synonyms | AI225843; B930003D11Rik; MUPP1; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000099894 | ||||||||||||||||||||||
InnateDB Gene | IDBG-159280 (Mpdz) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and amygdaloid nuclei but also detected in the subiculum and olfactory bulb. In the cerebellum, the highest level of expression was found in Purkinje cells. Moderately expressed in the granular layer and molecular layer. Expressed in the pontine nuclei, parts of spinal trigeminal nuclei, and the principal sensory trigeminal nuclei of the metencephalon. Expressed in all thalamic and hypothalamic nuclei, and the substantia nigra (at protein level). Ubiquitously expressed. {ECO:0000269PubMed:11018522, ECO:0000269PubMed:12706259}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1343489 | ||||||||||||||||||||||
InterPro |
IPR001478
PDZ domain IPR004172 L27 IPR015132 L27-2 |
||||||||||||||||||||||
PFAM |
PF00595
PF13180 PF09045 |
||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00228
SM00569 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8VBX6 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8VBX6 | ||||||||||||||||||||||
TrEMBL | B2RQR2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17475 | ||||||||||||||||||||||
UniGene | Mm.397399 | ||||||||||||||||||||||
RefSeq | NP_034950 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Mpdz | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS18292 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF000168 AF326526 AF326527 AF326528 AF326529 AF326530 AF326531 AF326532 AF326533 AF326534 AF326535 AF326536 AF326537 AF326538 AF326539 AF326540 AF326541 AF326542 AF326543 AF326544 AJ131869 AK031321 AK051782 AL670939 BC061504 BC138045 BC145117 CR352325 | ||||||||||||||||||||||
GenPept | AAB57835 AAH61504 AAI38046 AAI45118 AAL37372 AAL37373 AAL37374 AAL37375 AAL37376 AAL37377 AAL37378 AAL37379 AAL37380 AAL37381 AAL37382 AAL37383 AAL37384 AAL37385 AAL37386 AAL37387 AAL37388 AAL37389 AAL37390 BAC27346 BAC34766 CAA10523 CAI25220 CAI25921 | ||||||||||||||||||||||