InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfib

Summary

InnateDB Protein

IDBP-159423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfib

Protein Name

nuclear factor I/B

Synonyms

6720429L07Rik; CTF; E030026I10Rik; NF-I/B; NF1-B; NFI-B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052863

InnateDB Gene

IDBG-159419 (Nfib)

Protein Structure

UniProt Annotation

Function

Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest expression in lung, skeletal muscle and heart. Lower levels in liver, kidney and brain. Very low levels in testis and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002062	chondrocyte differentiation
GO:0006260	DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010001	glial cell differentiation
GO:0021740	principal sensory nucleus of trigeminal nerve development
GO:0021960	anterior commissure morphogenesis
GO:0030324	lung development
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0043392	negative regulation of DNA binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060486	Clara cell differentiation
GO:0060509	Type I pneumocyte differentiation
GO:0060510	Type II pneumocyte differentiation
GO:0061141	lung ciliated cell differentiation
GO:0071679	commissural neuron axon guidance
GO:2000791	negative regulation of mesenchymal cell proliferation involved in lung development
GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0044300	cerebellar mossy fiber

Protein Structure and Domains

PDB ID

MGI:103188

InterPro

IPR000647 CTF transcription factor/nuclear factor 1
IPR003619 MAD homology 1, Dwarfin-type
IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain

PFAM

PF00859
PF03165
PF10524

PRINTS

PIRSF

SMART

SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97863