Version 5.4
Mus musculus Protein: Acta2
Summary
InnateDB Protein IDBP-159495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acta2
Protein Name actin, alpha 2, smooth muscle, aorta
Synonyms 0610041G09Rik; a-SMA; Actvs; alphaSMA; SMalphaA;
Species Mus musculus
Ensembl Protein ENSMUSP00000048218
InnateDB Gene IDBG-159493 (Acta2)
Protein Structure
UniProt Annotation
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular Localization Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0008217 regulation of blood pressure
GO:0009615 response to virus
GO:0014829 vascular smooth muscle contraction
GO:0072144 glomerular mesangial cell development
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0030485 smooth muscle contractile fiber
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:87909
InterPro IPR004000 Actin-related protein
PFAM PF00022
PRINTS PR00190
PIRSF
SMART SM00268
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62737
PhosphoSite PhosphoSite-P62737
TrEMBL
UniProt Splice Variant
Entrez Gene 11475
UniGene
RefSeq NP_031418
MGI ID
MGI Symbol Acta2
OMIM
CCDS CCDS29757
HPRD
IMGT
EMBL AK017374 BC064800 M57409 X13297
GenPept AAH64800 BAB30715 CAA31659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca