InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fas

Summary

InnateDB Protein

IDBP-159579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fas

Protein Name

Fas (TNF receptor superfamily member 6)

Synonyms

AI196731; APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025691

InnateDB Gene

IDBG-159577 (Fas)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.

Tissue Specificity

Detected in various tissues including thymus, liver, lung, heart, and adult ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0042802	identical protein binding

Biological Process

GO:0002377	immunoglobulin production
GO:0003014	renal system process
GO:0006915	apoptotic process
GO:0006924	activation-induced cell death of T cells
GO:0006925	inflammatory cell apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0007165	signal transduction
GO:0007623	circadian rhythm
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636	response to toxic substance
GO:0010467	gene expression
GO:0010940	positive regulation of necrotic cell death
GO:0019724	B cell mediated immunity
GO:0032464	positive regulation of protein homooligomerization
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045060	negative thymic T cell selection
GO:0045619	regulation of lymphocyte differentiation
GO:0045637	regulation of myeloid cell differentiation
GO:0048536	spleen development
GO:0050869	negative regulation of B cell activation
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0051402	neuron apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:0071285	cellular response to lithium ion
GO:0071455	cellular response to hyperoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097049	motor neuron apoptotic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097527	necroptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome