InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk38

Summary

InnateDB Protein

IDBP-159637.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk38

Protein Name

serine/threonine kinase 38

Synonyms

5830476G13Rik; 9530097A09Rik; AA617404; Ndr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009138

InnateDB Gene

IDBG-159635 (Stk38)

Protein Structure

UniProt Annotation

Function

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in spleen, lung, thymus, brain and fat tissue. {ECO:0000269PubMed:15037617}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0043407	negative regulation of MAP kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0070688	MLL5-L complex

Protein Structure and Domains

PDB ID

MGI:2442572

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt