InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cer1

Summary

InnateDB Protein

IDBP-159645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cer1

Protein Name

cerberus 1 homolog (Xenopus laevis)

Synonyms

cer-1; Cerl; Cerl1; Cerr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048607

InnateDB Gene

IDBG-159643 (Cer1)

Protein Structure

UniProt Annotation

Function

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak. {ECO:0000269PubMed:12431380, ECO:0000269PubMed:9431803, ECO:0000269PubMed:9501024, ECO:0000269PubMed:9600941}.

Subcellular Localization

Secreted {ECO:0000269PubMed:9431803}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0016015	morphogen activity
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001657	ureteric bud development
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030282	bone mineralization
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0035582	sequestering of BMP in extracellular matrix
GO:0042074	cell migration involved in gastrulation
GO:0048263	determination of dorsal identity
GO:0071773	cellular response to BMP stimulus
GO:2000381	negative regulation of mesoderm development