InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctla4

Summary

InnateDB Protein

IDBP-159664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctla4

Protein Name

cytotoxic T-lymphocyte-associated protein 4

Synonyms

Cd152; Ctla-4; Ly-56;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027164

InnateDB Gene

IDBG-159662 (Ctla4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0030889	negative regulation of B cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0050777	negative regulation of immune response
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0009897	external side of plasma membrane
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:88556

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008096 Cytotoxic T-lymphocyte antigen 4
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PR01720

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt