InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lipa

Summary

InnateDB Protein

IDBP-159669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lipa

Protein Name

lysosomal acid lipase A

Synonyms

AA960673; Lal; Lip-1; Lip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053270

InnateDB Gene

IDBG-159667 (Lipa)

Protein Structure

UniProt Annotation

Function

Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Expressed at low levels in most tissues. High level expression is found in hepatocytes and splenic and thymic cells. Very high level expression is observed in cells of the small intestinal villi, the zona fasciculata and reticularis of the adrenal cortex, pancreatic acini, and renal tubular epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004771	sterol esterase activity
GO:0016298	lipase activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001816	cytokine production
GO:0006629	lipid metabolic process
GO:0006954	inflammatory response
GO:0008283	cell proliferation
GO:0016042	lipid catabolic process
GO:0030324	lung development
GO:0048771	tissue remodeling
GO:0048873	homeostasis of number of cells within a tissue