Version 5.4
Mus musculus Protein: Ngb
Summary
InnateDB Protein IDBP-159774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ngb
Protein Name neuroglobin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021420
InnateDB Gene IDBG-159772 (Ngb)
Protein Structure
UniProt Annotation
Function Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. {ECO:0000269PubMed:11473111, ECO:0000269PubMed:11473128}.
Subcellular Localization Perikaryon {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:22659017}. Mitochondrion {ECO:0000269PubMed:22659017}.
Disease Associations
Tissue Specificity Predominantly expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0006915 apoptotic process
GO:0015671 oxygen transport
Cellular Component
GO:0005739 mitochondrion
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID MGI:2151886
InterPro IPR000971 Globin
IPR009050 Globin-like
PFAM PF00042
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ER97
PhosphoSite PhosphoSite-
TrEMBL Q5ZPR7
UniProt Splice Variant
Entrez Gene 64242
UniGene Mm.41395
RefSeq NP_071859
MGI ID 3GLN
MGI Symbol Ngb
OMIM
CCDS CCDS36501
HPRD
IMGT
EMBL AJ245945 AJ580010 AK165775 BC024263 CH466590
GenPept AAH24263 BAE38375 CAC11135 CAE30466 EDL02920

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca