InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dscaml1

Summary

InnateDB Protein

IDBP-159804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dscaml1

Protein Name

Down syndrome cell adhesion molecule-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034592

InnateDB Gene

IDBG-159798 (Dscaml1)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells. {ECO:0000269PubMed:19945391}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

In the retina, expressed in the rod photoreceptors, AII amacrine cells and rod bipolar cells (at protein level). {ECO:0000269PubMed:19945391}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007156	homophilic cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007420	brain development
GO:0016338	calcium-independent cell-cell adhesion
GO:0048704	embryonic skeletal system morphogenesis
GO:0070593	dendrite self-avoidance

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2150309

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4VA61