InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Drd5

Summary

InnateDB Protein

IDBP-160025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drd5

Protein Name

dopamine receptor D5

Synonyms

D5R; Drd-5; Drd1b; Gpcr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039691

InnateDB Gene

IDBG-160023 (Drd5)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001588	dopamine receptor activity, coupled via Gs
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0035240	dopamine binding

Biological Process

GO:0001975	response to amphetamine
GO:0001992	regulation of systemic arterial blood pressure by vasopressin
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007617	mating behavior
GO:0008306	associative learning
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0019226	transmission of nerve impulse
GO:0033861	negative regulation of NAD(P)H oxidase activity
GO:0042060	wound healing
GO:0042220	response to cocaine
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045776	negative regulation of blood pressure
GO:0045924	regulation of female receptivity
GO:0046960	sensitization
GO:0060292	long term synaptic depression
GO:0071870	cellular response to catecholamine stimulus
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

MGI:94927

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000497 Dopamine D5 receptor
IPR000929 Dopamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00566
PR00242

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BLD9