InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPV17L

Summary

InnateDB Protein

IDBP-16010.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPV17L

Protein Name

MPV17 mitochondrial membrane protein-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000287594

InnateDB Gene

IDBG-16008 (MPV17L)

Protein Structure

UniProt Annotation

Function

Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes. {ECO:0000269PubMed:16631601}.

Subcellular Localization

Isoform 1: Peroxisome membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle. {ECO:0000269PubMed:16631601}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005102	receptor binding

Biological Process

GO:0010730	negative regulation of hydrogen peroxide biosynthetic process
GO:0072593	reactive oxygen species metabolic process
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway