Version 5.4
Mus musculus Protein: Ahsa1
Summary
InnateDB Protein IDBP-160212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ahsa1
Protein Name AHA1, activator of heat shock protein ATPase homolog 1 (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021425
InnateDB Gene IDBG-160210 (Ahsa1)
Protein Structure
UniProt Annotation
Function Co-chaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=May transiently interact with the endoplasmic reticulum. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0006950 response to stress
GO:0032781 positive regulation of ATPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2387603
InterPro IPR013538 Activator of Hsp90 ATPase homologue 1-like
IPR015310 Activator of Hsp90 ATPase, N-terminal
PFAM PF08327
PF09229
PRINTS
PIRSF
SMART SM01000
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BK64
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 217737
UniGene
RefSeq NP_666148
MGI ID
MGI Symbol Ahsa1
OMIM
CCDS CCDS26075
HPRD
IMGT
EMBL AK076069 BC023857 BC025552
GenPept AAH23857 AAH25552 BAC36160

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca