InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc14a1

Summary

InnateDB Protein

IDBP-160563.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc14a1

Protein Name

solute carrier family 14 (urea transporter), member 1

Synonyms

2610507K20Rik; 3021401A05Rik; UT-B; Utb1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089421

InnateDB Gene

IDBG-160561 (Slc14a1)

Protein Structure

UniProt Annotation

Function

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. {ECO:0000269PubMed:11792714, ECO:0000269PubMed:12133842}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Restricted to the basolateral membrane in various portions of the urothelium.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, heart, liver, lung, skeletal muscle, spleen, testis, ureter and urinary bladder (at protein level). Along the gastrointestinal tract, detected in colon, jejunum and stomach (at protein level). In the kidney, expressed in some microvessels of the inner and outer medulla, but not all (at protein level). Not detected in the cortex (at protein level). Detected in the urothelium all along the urinary tract, including the papilla surface, the ureter, the bladder and the urethra (at protein level). In the brain, expressed at the border of the corpus callosum and striatum in astrocytic cellular processes surrounding blood microvessels (at protein level). Detected in erythrocytes (at protein level). {ECO:0000269PubMed:11792714, ECO:0000269PubMed:12133842, ECO:0000269PubMed:15563580}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005372	water transmembrane transporter activity
GO:0015204	urea transmembrane transporter activity
GO:0015265	urea channel activity