InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rraga

Summary

InnateDB Protein

IDBP-161002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rraga

Protein Name

Ras-related GTP binding A

Synonyms

1300010C19Rik; AI255374; FIP-1; RAGA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088591

InnateDB Gene

IDBG-161000 (Rraga)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Lysosome {ECO:0000250}. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0006915	apoptotic process
GO:0007264	small GTPase mediated signal transduction
GO:0008219	cell death
GO:0019048	modulation by virus of host morphology or physiology
GO:0034613	cellular protein localization
GO:0045919	positive regulation of cytolysis
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1915691

InterPro

IPR001806 Small GTPase superfamily
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670

PRINTS

PR00449
PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80X95