InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Drd3

Summary

InnateDB Protein

IDBP-161126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drd3

Protein Name

dopamine receptor D3

Synonyms

D3R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023390

InnateDB Gene

IDBG-161124 (Drd3)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0019904	protein domain specific binding
GO:0031748	D1 dopamine receptor binding
GO:0035240	dopamine binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002031	G-protein coupled receptor internalization
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007626	locomotory behavior
GO:0008284	positive regulation of cell proliferation
GO:0008542	visual learning
GO:0014059	regulation of dopamine secretion
GO:0019216	regulation of lipid metabolic process
GO:0030814	regulation of cAMP metabolic process
GO:0032416	negative regulation of sodium:hydrogen antiporter activity
GO:0032467	positive regulation of cytokinesis
GO:0032922	circadian regulation of gene expression
GO:0034776	response to histamine
GO:0035483	gastric emptying
GO:0035815	positive regulation of renal sodium excretion
GO:0040012	regulation of locomotion
GO:0040014	regulation of multicellular organism growth
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0045187	regulation of circadian sleep/wake cycle, sleep
GO:0045471	response to ethanol
GO:0045776	negative regulation of blood pressure
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046717	acid secretion
GO:0048148	behavioral response to cocaine
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050883	musculoskeletal movement, spinal reflex action
GO:0051898	negative regulation of protein kinase B signaling
GO:0060134	prepulse inhibition
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0090325	regulation of locomotion involved in locomotory behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0042995	cell projection
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:94925

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR001620 Dopamine D3 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00242
PR00568

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30728