Version 5.4
| Mus musculus Protein: Dio2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-161132.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Dio2 | ||||||||
| Protein Name | deiodinase, iodothyronine, type II | ||||||||
| Synonyms | 5DII; AI324267; DIOII; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000081013 | ||||||||
| InnateDB Gene | IDBG-161130 (Dio2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in mammary gland and in brain. {ECO:0000269PubMed:10715551}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1338833 | ||||||||
| InterPro |
IPR000643
Iodothyronine deiodinase IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant IPR012336 Thioredoxin-like fold |
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| PFAM |
PF00837
PF00578 PF13098 PF13192 PF13462 PF13905 |
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| PRINTS | |||||||||
| PIRSF |
PIRSF001330
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| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9Z1Y9 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q9ES98 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 13371 | ||||||||
| UniGene | Mm.408815 | ||||||||
| RefSeq | NP_034180 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Dio2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36514 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF093137 AF096875 AF177196 AH009875 BC125383 BC125385 | ||||||||
| GenPept | AAD11422 AAD53113 AAF00069 AAG23127 AAI25384 AAI25386 | ||||||||