InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sertad1

Summary

InnateDB Protein

IDBP-161141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sertad1

Protein Name

SERTA domain containing 1

Synonyms

1110032C13Rik; AV000455; AW456625; Sei-1; Sei1; TRIP-Br1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008528

InnateDB Gene

IDBG-161139 (Sertad1)

Protein Structure

UniProt Annotation

Function

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A. {ECO:0000269PubMed:11331592}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected at in testis, lung and, at lower levels, in muscle, liver, spleen, brain and heart. {ECO:0000269PubMed:11331592}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0030308	negative regulation of cell growth
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1913438

InterPro

IPR009263 SERTA domain

PFAM

PF06031

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AC158304 AF218291 AF366400 AF366401 AK004022 AK008303 BC016077

GenPept

AAF27653 AAH16077 AAK52829 AAK52830 BAB23130 BAB25588

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca