InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc16a8

Summary

InnateDB Protein

IDBP-161219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc16a8

Protein Name

solute carrier family 16 (monocarboxylic acid transporters), member 8

Synonyms

Mct3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040522

InnateDB Gene

IDBG-161217 (Slc16a8)

Protein Structure

UniProt Annotation

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Retinal pigment epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity

Biological Process

GO:0015711	organic anion transport
GO:0015718	monocarboxylic acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1929519

InterPro

IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35308

PhosphoSite