InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: March5

Summary

InnateDB Protein

IDBP-161370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

March5

Protein Name

membrane-associated ring finger (C3HC4) 5

Synonyms

1810015H18Rik; 2310008I22Rik; 2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V; Marchv; MITOL; Rnf153;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024078

InnateDB Gene

IDBG-161368 (March5)

Protein Structure

UniProt Annotation

Function

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1 (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0051020	GTPase binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0051865	protein autoubiquitination
GO:0070585	protein localization to mitochondrion
GO:0090140	regulation of mitochondrial fission
GO:0090141	positive regulation of mitochondrial fission
GO:0090344	negative regulation of cell aging

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane