Version 5.4
Mus musculus Protein: Spice1
Summary
InnateDB Protein IDBP-161857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spice1
Protein Name spindle and centriole associated protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000058832
InnateDB Gene IDBG-161855 (Spice1)
Protein Structure
UniProt Annotation
Function Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0046599 regulation of centriole replication
GO:0051310 metaphase plate congression
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
Protein Structure and Domains
PDB ID MGI:1196252
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C804
PhosphoSite PhosphoSite-Q8C804
TrEMBL
UniProt Splice Variant
Entrez Gene 212514
UniGene Mm.412824
RefSeq NP_653133
MGI ID
MGI Symbol Spice1
OMIM
CCDS CCDS37345
HPRD
IMGT
EMBL AK048789 AY099108 BC052381 BC056960
GenPept AAH52381 AAH56960 AAM34496 BAC33458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca