InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Igbp1

Summary

InnateDB Protein

IDBP-162066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igbp1

Protein Name

immunoglobulin (CD79A) binding protein 1

Synonyms

AI115586; AI662457; AW208785; C81413; p52; Pc52; Tap42;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033570

InnateDB Gene

IDBG-162064 (Igbp1)

Protein Structure

UniProt Annotation

Function

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, liver and brain. Ubiquitously expressed in B lineage cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019904	protein domain specific binding
GO:0031434	mitogen-activated protein kinase kinase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0009966	regulation of signal transduction
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0034612	response to tumor necrosis factor
GO:0035306	positive regulation of dephosphorylation
GO:0035308	negative regulation of protein dephosphorylation
GO:0042113	B cell activation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060632	regulation of microtubule-based movement
GO:0070555	response to interleukin-1
GO:2001234	negative regulation of apoptotic signaling pathway