InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtpbp1

Summary

InnateDB Protein

IDBP-162391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtpbp1

Protein Name

GTP binding protein 1

Synonyms

AL022987; AW045683; C85212; GP-1; Gtpbp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043575

InnateDB Gene

IDBG-162385 (Gtpbp1)

Protein Structure

UniProt Annotation

Function

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10938096}.

Disease Associations

Tissue Specificity

Detected in some neurons in the brain cortex. Detected in small arteries, dendritic cells and macrophages in the thymus. Detected in lung bronchi, in bronchial epithelial cells and in bronchial smooth muscle cells. Detected in smooth muscle cells in a broad range of organs (at protein level). Expressed in brain, thymus, lung, and kidney. {ECO:0000269PubMed:10938096, ECO:0000269PubMed:9070279}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0061014	positive regulation of mRNA catabolic process

Cellular Component

GO:0000177	cytoplasmic exosome (RNase complex)
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:109443

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08582