InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pklr

Summary

InnateDB Protein

IDBP-162644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pklr

Protein Name

pyruvate kinase liver and red blood cell

Synonyms

Pk-1; Pk1; R-PK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035417

InnateDB Gene

IDBG-162642 (Pklr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004743	pyruvate kinase activity
GO:0030955	potassium ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0006754	ATP biosynthetic process
GO:0007584	response to nutrient
GO:0009408	response to heat
GO:0009749	response to glucose
GO:0010038	response to metal ion
GO:0010226	response to lithium ion
GO:0014070	response to organic cyclic compound
GO:0016310	phosphorylation
GO:0032869	cellular response to insulin stimulus
GO:0033198	response to ATP
GO:0042866	pyruvate biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0051591	response to cAMP
GO:0051707	response to other organism

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97604

InterPro

IPR001697 Pyruvate kinase
IPR011037 Pyruvate kinase-like, insert domain
IPR015793 Pyruvate kinase, barrel
IPR015795 Pyruvate kinase, C-terminal
IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain

PFAM

PF00224
PF02887

PRINTS

PR01050

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite