Version 5.4
Mus musculus Protein: Ifne
Summary
InnateDB Protein IDBP-162817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ifne
Protein Name interferon epsilon
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000059199
InnateDB Gene IDBG-162815 (Ifne)
Protein Structure
UniProt Annotation
Function Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections. {ECO:0000269PubMed:23449591}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at very high levels in uterus and, at much lower levels, in ovary and cervix. Very low levels, if any, in other organs. In the endometrium, expressed in the luminal and glandular epithelial cells (at protein level). {ECO:0000269PubMed:15233997, ECO:0000269PubMed:23449591}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
Biological Process
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100 B cell proliferation
GO:0042742 defense response to bacterium
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response (InnateDB)
GO:0045343 regulation of MHC class I biosynthetic process
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:2667156
InterPro IPR000471 Interferon alpha/beta/delta
IPR009079 Four-helical cytokine-like, core
PFAM PF00143
PRINTS PR00266
PIRSF
SMART SM00076
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80ZF2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 230405
UniGene Mm.246593
RefSeq NP_796322
MGI ID
MGI Symbol Ifne
OMIM
CCDS CCDS18348
HPRD
IMGT
EMBL AL805899 AY190044 BC104376 BC104377
GenPept AAI04377 AAI04378 AAO38685 CAM23377

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca