Version 5.4
Mus musculus Protein: Ngdn
Summary
InnateDB Protein IDBP-162888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ngdn
Protein Name neuroguidin, EIF4E binding protein
Synonyms 1500001L15Rik; neuroguidin; Ngd;
Species Mus musculus
Ensembl Protein ENSMUSP00000022815
InnateDB Gene IDBG-162886 (Ngdn)
Protein Structure
UniProt Annotation
Function Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner. {ECO:0000269PubMed:16705177}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16705177}. Nucleus, nucleolus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:16705177}. Cell projection, axon {ECO:0000269PubMed:16705177}. Cell projection, dendrite {ECO:0000269PubMed:16705177}. Cell projection, filopodium {ECO:0000269PubMed:16705177}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in testis, ovary, spleen, kidney, hippocampus and cerebellum (at protein level). Expressed in testis, ovary, spleen, kidney, brain. {ECO:0000269PubMed:16705177}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
Protein Structure and Domains
PDB ID MGI:1916216
InterPro IPR007146 Sas10/Utp3/C1D
PFAM PF04000
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DB96
PhosphoSite PhosphoSite-Q9DB96
TrEMBL B0LAE8
UniProt Splice Variant
Entrez Gene 68966
UniGene Mm.21214
RefSeq NP_081166
MGI ID
MGI Symbol Ngdn
OMIM
CCDS CCDS36928
HPRD
IMGT
EMBL AK005098 BC023770 BC052790 EF437387
GenPept AAH23770 AAH52790 ABS83542 BAB23816

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca