InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tenm2

Summary

InnateDB Protein

IDBP-163028.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tenm2

Protein Name

odd Oz/ten-m homolog 2 (Drosophila)

Synonyms

Odz2; Odz3; Ten-2; Ten-m2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052014

InnateDB Gene

IDBG-163024 (Tenm2)

Protein Structure

UniProt Annotation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the LPHN1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). {ECO:0000250}.Ten-2 intracellular domain: Induces gene transcription inhibition. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with LPHN1 across intercellular junctions. {ECO:0000250}.Ten-2 intracellular domain: Nucleus, PML body {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the cortex, CA1, CA2, CA3, dentate gyrus and granular layer of the hippocampus. Expressed in the Purkinje cells and molecular layer of the cerebellum. {ECO:0000269PubMed:12915301}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0097264	self proteolysis

Cellular Component

GO:0005911	cell-cell junction
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1345184

InterPro

IPR000742 Epidermal growth factor-like domain
IPR006530 YD repeat
IPR008969 Carboxypeptidase-like, regulatory domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR008996 Cytokine, IL-1-like
IPR009471 Teneurin intracellular, N-terminal
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR013111 EGF-like domain, extracellular
IPR022385 Rhs repeat-associated core

PFAM

PF00008
PF05593
PF06484
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite