Version 5.4
Mus musculus Protein: Tmem59l
Summary
InnateDB Protein IDBP-163101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem59l
Protein Name transmembrane protein 59-like
Synonyms 5330410G16Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000043659
InnateDB Gene IDBG-163099 (Tmem59l)
Protein Structure
UniProt Annotation
Function Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0000139 Golgi membrane
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915187
InterPro IPR022065 Uncharacterised protein family, TMEM59
PFAM PF12280
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TNI2
PhosphoSite PhosphoSite-Q7TNI2
TrEMBL
UniProt Splice Variant
Entrez Gene 67937
UniGene Mm.23002
RefSeq NP_892036
MGI ID
MGI Symbol Tmem59l
OMIM
CCDS CCDS22368
HPRD
IMGT
EMBL BC056172
GenPept AAH56172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca