Version 5.4
Mus musculus Protein: Ptdss1
Summary
InnateDB Protein IDBP-163190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptdss1
Protein Name phosphatidylserine synthase 1
Synonyms AU044268; AW539008; mKIAA0024; PSS-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000021990
InnateDB Gene IDBG-163188 (Ptdss1)
Protein Structure
UniProt Annotation
Function Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. {ECO:0000269PubMed:10432300, ECO:0000269PubMed:9516423}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:10938271}; Multi-pass membrane protein {ECO:0000269PubMed:10938271}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Disease Associations
Tissue Specificity Expressed in kidney, testis, lung, skeletal muscle, liver brain, heart and spleen with highest expression in testis, liver, heart and brain. {ECO:0000269PubMed:10432300}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
Biological Process
GO:0006659 phosphatidylserine biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1276575
InterPro IPR004277 Phosphatidyl serine synthase
PFAM PF03034
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LH2
PhosphoSite PhosphoSite-Q99LH2
TrEMBL
UniProt Splice Variant
Entrez Gene 19210
UniGene Mm.402676
RefSeq NP_032985
MGI ID
MGI Symbol Ptdss1
OMIM
CCDS CCDS26612
HPRD
IMGT
EMBL AF042731 AK036990 AK054101 AK085857 AK088048 AK137681 BC003260
GenPept AAB97845 AAH03260 BAC29660 BAC35656 BAC39555 BAC40117 BAE23459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca