Version 5.4
Mus musculus Protein: Hmmr
Summary
InnateDB Protein IDBP-163244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmmr
Protein Name hyaluronan mediated motility receptor (RHAMM)
Synonyms AA386826; CD168; Rhamm;
Species Mus musculus
Ensembl Protein ENSMUSP00000020579
InnateDB Gene IDBG-163242 (Hmmr)
Protein Structure
UniProt Annotation
Function Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.
Subcellular Localization Cell surface. Cytoplasm.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:9889313}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005540 hyaluronic acid binding
Biological Process
GO:0000160 phosphorelay signal transduction system
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:104667
InterPro IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain
PFAM PF01627
PRINTS
PIRSF
SMART SM00073
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q00547
PhosphoSite PhosphoSite-Q00547
TrEMBL Q3UPW7
UniProt Splice Variant
Entrez Gene 15366
UniGene Mm.405367
RefSeq NP_038580
MGI ID
MGI Symbol Hmmr
OMIM
CCDS CCDS24548
HPRD
IMGT
EMBL AF031932 AF079222 AJ005919 AJ005920 AJ005921 AJ005922 AJ005923 AJ005924 AK143123 AK164410 AK164597 AL646055 CH466609 X64550
GenPept AAC12655 AAD08670 BAE25277 BAE37775 BAE37844 CAA06768 CAA45848 CAA45849 CAI25425 EDL32330

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca