InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc50a1

Summary

InnateDB Protein

IDBP-163693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc50a1

Protein Name

solute carrier family 50 (sugar transporter), member 1

Synonyms

MmSWEET1; Rag1ap1; Rga;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029565

InnateDB Gene

IDBG-163691 (Slc50a1)

Protein Structure

UniProt Annotation

Function

Mediates sugar transport across membranes (By similarity). May regulate the expression of RAG1 a gene involved in V(D)J recombination. {ECO:0000250, ECO:0000269PubMed:8630032}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=May also localize to the endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in lung, placenta, spleen and thymus, at intermediate levels in brain, heart, kidney and testis, and at low levels in bone marrow, liver and lymph node. Within the thymus expression is highest in non-lymphoid cells. {ECO:0000269PubMed:8630032}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042947	glucoside transmembrane transporter activity
GO:0051119	sugar transmembrane transporter activity

Biological Process

GO:0006310	DNA recombination
GO:0034219	carbohydrate transmembrane transport
GO:0042946	glucoside transport
GO:0045815	positive regulation of gene expression, epigenetic