Mus musculus Protein: Dlat
Summary
InnateDB Protein IDBP-163714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlat
Protein Name dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000034567
InnateDB Gene IDBG-163712 (Dlat)
Protein Structure
UniProt Annotation
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
GO:0005515 protein binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006006 glucose metabolic process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0006090 pyruvate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005967 mitochondrial pyruvate dehydrogenase complex
GO:0045254 pyruvate dehydrogenase complex
Protein Structure and Domains
PDB ID MGI:2385311
InterPro IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR004167 E3 binding
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR011053 Single hybrid motif
PFAM PF00364
PF00198
PF02817
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMF4
PhosphoSite PhosphoSite-Q8BMF4
TrEMBL
UniProt Splice Variant
Entrez Gene 235339
UniGene Mm.471144
RefSeq NP_663589
MGI ID
MGI Symbol Dlat
OMIM
CCDS CCDS23168
HPRD
IMGT
EMBL AK032124 AY044265 BC026680 BC031495 BC069862
GenPept AAH26680 AAH31495 AAH69862 AAL02400 BAC27715