InnateDB Protein
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IDBP-16392.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TADA3
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Protein Name
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transcriptional adaptor 3
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Synonyms
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ADA3; hADA3; NGG1; STAF54; TADA3L;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000307684
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InnateDB Gene
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IDBG-16388 (TADA3)
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Protein Structure
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Function |
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269PubMed:11707411, ECO:0000269PubMed:19103755}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11564863, ECO:0000269PubMed:9674425}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
55
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003713
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transcription coactivator activity
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GO:0004402
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histone acetyltransferase activity
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GO:0005515
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protein binding
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GO:0016922
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ligand-dependent nuclear receptor binding
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GO:0019904
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protein domain specific binding
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019340
Histone acetyltransferases subunit 3
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PFAM |
PF10198
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75528
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PhosphoSite |
PhosphoSite-O75528
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TrEMBL |
C9JMS0
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UniProt Splice Variant |
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Entrez Gene |
10474
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UniGene |
Hs.386390
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RefSeq |
NP_006345
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HUGO |
HGNC:19422
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OMIM |
602945
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CCDS |
CCDS2583
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HPRD |
04252
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IMGT |
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EMBL |
AC022382
AF069733
AK000228
AL117487
BC009240
BC013433
CH471055
CR533543
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GenPept |
AAC39903
AAH09240
AAH13433
CAB55957
CAG38574
EAW63994
EAW63997
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