InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pck2

Summary

InnateDB Protein

IDBP-163925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pck2

Protein Name

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

Synonyms

1810010O14Rik; 9130022B02Rik; PEPCK-M;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038555

InnateDB Gene

IDBG-163923 (Pck2)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004611	phosphoenolpyruvate carboxykinase activity
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017076	purine nucleotide binding
GO:0046872	metal ion binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006094	gluconeogenesis
GO:0006107	oxaloacetate metabolic process
GO:0006116	NADH oxidation
GO:0032024	positive regulation of insulin secretion
GO:0051384	response to glucocorticoid
GO:0071333	cellular response to glucose stimulus