InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TADA3

Summary

InnateDB Protein

IDBP-16396.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TADA3

Protein Name

transcriptional adaptor 3

Synonyms

ADA3; hADA3; NGG1; STAF54; TADA3L;

Species

Homo sapiens

Ensembl Protein

ENSP00000343649

InnateDB Gene

IDBG-16388 (TADA3)

Protein Structure

UniProt Annotation

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269PubMed:11707411, ECO:0000269PubMed:19103755}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11564863, ECO:0000269PubMed:9674425}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0043966	histone H3 acetylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex