InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spag16

Summary

InnateDB Protein

IDBP-164301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spag16

Protein Name

sperm associated antigen 16

Synonyms

4921511D23Rik; 4930524F24Rik; 4930585K05Rik; AV261009; Pf20; Wdr29;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069821

InnateDB Gene

IDBG-164299 (Spag16)

Protein Structure

UniProt Annotation

Function

Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia. {ECO:0000269PubMed:19305393}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Note=Detected on the sperm flagellum. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:12391165}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0007283	spermatogenesis
GO:0042384	cilium assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005930	axoneme
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1913972

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K450

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

66722

UniGene

Mm.440554

RefSeq

NP_083436

MGI ID

MGI Symbol

Spag16

OMIM

CCDS

CCDS15027

HPRD

IMGT

EMBL

AF490391 AK014865 AK015884 AK016618 AK083083 BC120668

GenPept

AAI20669 AAM97148 BAB29591 BAB30016 BAB30341 BAC38755