InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stom

Summary

InnateDB Protein

IDBP-164423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stom

Protein Name

stomatin

Synonyms

Epb7.2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028241

InnateDB Gene

IDBG-164421 (Stom)

Protein Structure

UniProt Annotation

Function

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. {ECO:0000269PubMed:15471860, ECO:0000269PubMed:22850675}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome {ECO:0000250}. Cytoplasmic vesicle. Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin.

Disease Associations

Tissue Specificity

Expressed in all sensory neurons of the dorsal root ganglia. In the CNS, expressed in many neurons of the spinal cord, medulla and pons. Expressed only in scattered neurons in the cortex, hippocampus, thalamus and basal ganglia. In the cerebellum, expressed in all Purkinje cells (at protein level). Widely expressed with high levels in heart, liver, skeletal muscle and testis and low levels in lung, brain and spleen. {ECO:0000269PubMed:10383825, ECO:0000269PubMed:7540886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:1901585	regulation of acid-sensing ion channel activity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042470	melanosome
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle