InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgfa

Summary

InnateDB Protein

IDBP-164486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgfa

Protein Name

transforming growth factor alpha

Synonyms

wa-1; wa1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032066

InnateDB Gene

IDBG-164484 (Tgfa)

Protein Structure

UniProt Annotation

Function

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Subcellular Localization

Transforming growth factor alpha: Secreted, extracellular space.Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004708	MAP kinase kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0048523	negative regulation of cellular process
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051781	positive regulation of cell division
GO:0060749	mammary gland alveolus development

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0048471	perinuclear region of cytoplasm