InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ebf1

Summary

InnateDB Protein

IDBP-164726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ebf1

Protein Name

early B-cell factor 1

Synonyms

Ebf; O/E-1; OE-1; Olf-1; Olf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080020

InnateDB Gene

IDBG-164722 (Ebf1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000269PubMed:20876732}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at high levels in early B-cells, spleen, lymph node and adipose tissue, and at low levels in heart, brain, skeletal muscle and kidney. In adult expressed in olfactory epithelium, in spleen, and at a lesser extent in Purkinje cells of the cerebellum, heart, kidney, lung, thymus and testis. In embryo expressed in dorsal thalamus and epithalamus, at a lower level in mesencephalon and in the caudal rhombencephalon, in the postmitotic cells of developing retina, highly in developing spinal cord, dorsal root ganglia, trigeminal ganglia and in glossopharyngeal nerve ganglia, in developing inner ear.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	1 [view]
Protein-DNA	11 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0045893	positive regulation of transcription, DNA-templated