InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cryaa

Summary

InnateDB Protein

IDBP-164760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cryaa

Protein Name

crystallin, alpha A

Synonyms

Acry-1; Crya-1; Crya1; DAcry-1; lop18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019192

InnateDB Gene

IDBG-164758 (Cryaa)

Protein Structure

UniProt Annotation

Function

Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0002088	lens development in camera-type eye
GO:0002089	lens morphogenesis in camera-type eye
GO:0006457	protein folding
GO:0006915	apoptotic process
GO:0007005	mitochondrion organization
GO:0007015	actin filament organization
GO:0007017	microtubule-based process
GO:0007021	tubulin complex assembly
GO:0007601	visual perception
GO:0010288	response to lead ion
GO:0010629	negative regulation of gene expression
GO:0030307	positive regulation of cell growth
GO:0032387	negative regulation of intracellular transport
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048596	embryonic camera-type eye morphogenesis
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0060561	apoptotic process involved in morphogenesis
GO:0070141	response to UV-A
GO:0070309	lens fiber cell morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:88515

InterPro

IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR003090 Alpha-crystallin, N-terminal
IPR008978 HSP20-like chaperone

PFAM

PF00011
PF00525

PRINTS

PR00299

PIRSF

PIRSF036514

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt