InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: S100b

Summary

InnateDB Protein

IDBP-164810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100b

Protein Name

S100 protein, beta polypeptide, neural

Synonyms

AI850290; Bpb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047968

InnateDB Gene

IDBG-164808 (S100b)

Protein Structure

UniProt Annotation

Function

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0048156	tau protein binding
GO:0048306	calcium-dependent protein binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0007611	learning or memory
GO:0007613	memory
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0042035	regulation of cytokine biosynthetic process
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048708	astrocyte differentiation
GO:0050806	positive regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051597	response to methylmercury
GO:0060291	long-term synaptic potentiation
GO:0071456	cellular response to hypoxia
GO:2001015	negative regulation of skeletal muscle cell differentiation

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm