InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tef

Summary

InnateDB Protein

IDBP-165293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tef

Protein Name

thyrotroph embryonic factor

Synonyms

2310028D20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023024

InnateDB Gene

IDBG-165289 (Tef)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3' (By similarity). Also activates the telokin promoter in smooth muscle-specific and calcium-dependent manner. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform Alpha and isoform Beta are expressed at high levels in lung, bladder, kidney, gut and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048511	rhythmic process