Version 5.4
Mus musculus Protein: Phf5a
Summary
InnateDB Protein IDBP-165408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phf5a
Protein Name PHD finger protein 5A
Synonyms 1110007B08Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000023117
InnateDB Gene IDBG-165406 (Phf5a)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Nucleus speckle.
Disease Associations
Tissue Specificity Expressed in primary spermatocytes (at protein level). Ubiquitously expressed in pre- and postnatal tissues. {ECO:0000269PubMed:12054543, ECO:0000269PubMed:18758164}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:2156864
InterPro IPR005345 PHF5-like
PFAM PF03660
PRINTS
PIRSF PIRSF016468
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P83870
PhosphoSite PhosphoSite-P83870
TrEMBL
UniProt Splice Variant
Entrez Gene 68479
UniGene Mm.271715
RefSeq NP_081013
MGI ID
MGI Symbol Phf5a
OMIM
CCDS CCDS27674
HPRD
IMGT
EMBL AF479286 AF479288 AK003520 AK143590 AK163247 AK167932 AK167955 BC025161
GenPept AAH25161 AAM49735 AAM49736 BAB22833 BAE25453 BAE37255 BAE39936 BAE39955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca