InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pgm1

Summary

InnateDB Protein

IDBP-165534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pgm1

Protein Name

phosphoglucomutase 1

Synonyms

3230402E02Rik; Pgm-1; Pgm2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084582

InnateDB Gene

IDBG-165532 (Pgm1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in lung, spleen and thymus. Expressed at lower levels in liver, brain, kidney, skeletal muscle, testis and heart. {ECO:0000269PubMed:17804405}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004614	phosphoglucomutase activity
GO:0008973	phosphopentomutase activity
GO:0016868	intramolecular transferase activity, phosphotransferases

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006006	glucose metabolic process
GO:0019388	galactose catabolic process
GO:0046386	deoxyribose phosphate catabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

MGI:97564

InterPro

IPR005843 Alpha-D-phosphohexomutase, C-terminal
IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II
IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III
IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III

PFAM

PF00408
PF02878
PF02879
PF02880

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TSV4

PhosphoSite