InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pecr

Summary

InnateDB Protein

IDBP-165548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pecr

Protein Name

peroxisomal trans-2-enoyl-CoA reductase

Synonyms

2400003B18Rik; TERP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027381

InnateDB Gene

IDBG-165546 (Pecr)

Protein Structure

UniProt Annotation

Function

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in liver and kidney. Expressed at lowe level in heart and skeletal muscle. Expressed at weak level in other tissues. {ECO:0000269PubMed:10811639}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity

Biological Process

GO:0008152	metabolic process
GO:0030497	fatty acid elongation
GO:0033306	phytol metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2148199

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt